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Open-label Add-on Treatment Trial of Minocycline in Fragile X Syndrome

Conclusions

Results from this study demonstrate that minocycline provides significant functional benefits to FXS patients and that it is well-tolerated. These findings are consistent with the fmr1 knockout mouse model results, suggesting that minocycline modifies underlying neural defects that account for behavioural abnormalities. A placebo-controlled trial of minocycline in FXS is warranted. Trial registration: ClinicalTrials.gov Open-Label Trial NCT00858689

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Originally posted on BioMed Central.

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